Research
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Circadian Drive, Alertness and Mental Performance

A time to remember – the role of circadian clocks in learning and memory
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Amplitude Reduction and Phase Shifts of Melatonin, Cortisol and Other Circadian Rhythms after a gradual Advance of Sleep and Light Exposure in Humans
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Environmental 24-hr Cycles Are Essential for Health
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Improved neurobehavioral performance during the wake maintenance zone
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Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioral performance
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Modeling Napping, Post-Lunch Dip, and Other Variations in Human Sleep Propensity
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Morning Sleep Inertia in Alertness and Performance – Effect of Cognitive Domain and White Light Conditions
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Relationship between alertness, performance, and body temperature in humans
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Short Wavelength Light Enhances Cortisol Awakening Response in Sleep-Restricted Adolescents
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Systems Biology of Circadian Rhythms – An Outlook
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The Cortisol Awakening Response – Facts and Future Directions
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The cortisol awakening response – more than a measure of HPA axis function
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The forbidden zone for sleep and its biological purpose is to enhance survival
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Time to decide – diurnal variation on the speed and quality of human decisions
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Timing and Consolidation of Human Sleep, Wakefulness, and Performance by a Symphony of Oscillators
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Social Jet Lag and Light at Night

Ancestral sleep
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Circadian Entrainment to the Natural Light-Dark Cycle Across Seasons and the Weekend
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Crosstalk Between Environmental Light and Internal Time in Humans
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Digital Sleep Logs Reveal Potential Impacts of Modern Temporal Structure on Class Performance in Different Chronotypes
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Endocrine Effects of Circadian Disruption
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Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle
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Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness
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Global rise of potential health hazards caused by blue light-induced circadian disruption in modern aging societies
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Light Hygiene – Time to make preventative use of insights – old and new – into the nexus of the drug light, melatonin, clocks, chronodisruption and public health
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Nocturnal light pollution and underexposure to daytime sunlight Complementary mechanisms of circadian disruption and related diseases
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Protecting the Melatonin Rhythm through Circadian Healthy Light Exposure
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Sleep Fragmentation and the risk of Incident Alzheimer’s Disease and Cognitive Decline in Older Persons
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Sleep in adolescents – the perfect storm
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Social Jet Lab and Obesity
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Social Jetlag – Misalignment of Biological and Social Time
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Synchronization of biological clock neurons by light and peripheral feedback systems promotes circadian rhythms and health
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The Circadian Clock and Human Health
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The effects of self-selected light-dark cycles and social constraints on human sleep and circadian timing – a modeling approach
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Field Applications and Studies

A 10am School Start Time Improves Health and Performance of Students Aged 13-16
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Aging Reduces the Stimulating Effect of Blue Light on Cognitive Brain Functions
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Alzheimers pilot study
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Buying Time – a rationale for examining the use of circadian rhythm and sleep interventions to delay progression of mild cognitive impairment to Alzheimers disease
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Circadian timing and age
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Correcting Delayed Circadian Phase with Bright Light Therapy Predicts Improvement in ADHD Symptoms
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Decreased Sensitivity to Phase Delaying Effects of Moderate intensity light in older subjects
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Irregular sleep wake patterns are associated with poorer academic performance and delayed circadian and sleep-wake timing
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Lower School Performance in Late Chronotypes – Underlying Factors and Mechanisms
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Progression of Dementia Assessed by Temporal Correlations of Physical Activity – Results from a 3_5 year, longitudinal randomized controlled trial
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Lighting Design Parameters

Color and spectral analysis of daylight in southern Europe
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Dim light adaptation attenuates acute melatonin suppression in humans
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Direct Effects of Light on Alertness, Vigilance, and the Waking EEG in Humans Depend on Prior Light History
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Inferior Retinal Light Exposure is More Effective than Superior Retinal Exposure in Suppressing Melatonin in Humans
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Melatonin Suppression by Illumination of Upper and Lower Visual Fields
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Peripheral Vision Suppression of Melatonin
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The Human Circadian System Adapts to Prior Photic History
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Circadian Photoreception

Action Spectrum for melatonin regulation in humans – evidence for a novel circadian photoreceptor
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An action spectrum for melatonin suppression – evidence for a novel non-rod, non-cone photoreceptor system in humans
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Dim light adaptation attenuates acute melatonin suppression in humans
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Human responses to bright light of different durations
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Mammalian Inner Retinal Photoreception
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Measuring and using light in the melanopsin age
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Melanopsin-containing retinal ganglion cells – architecture, projections, and intrinsic photosensitivity
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Phototransduction by Retinal Ganglion Cells that Set the Circadian Clock
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Short Wavelength enrichment of polychromatic light enhances human melatonin suppression potency
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Signalling by melanopsin (OPN4) expressing photosensitive retinal ganglion cells
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Suppression of melatonin secretion in some blind patients by exposure to bright light
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Using light to tell time of day – sensory coding in the mammalian circadian visual network
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Bad Blue

The stimulating effect of bright light on physical performance depends on internal time
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Effects of blue light on the circadian system and eye physiology
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Effects of light-emitting dioge radiations on human retinal pigment epithelial cells in vitro
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Light emitting diodes for domestic lighting – any risks for the eye?
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Light induced retinal damage using different light sources, protocols and rat strains reveals led phototoxicity
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Retinal damage induced by commercial light emitting diodes
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The susceptibility of the retina to photochemical damage from visible light
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White light emitting diodes at domestic lighting levels and retinal injury in a rat model
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Skin Response and Far-red benefits

670nm light mitigates oxygen-induced degeneration in mouse retina
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A controlled trial to determine the efficacy of red and near-infrared light treatment in patient satisfaction, reduction of fine lines, wrinkles, skin roughness, and intradermal collagen density increase
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Aging retinal function is improved by near infrared light 670nm that is associated with corrected mitochrondrial decline
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Differential effects of 670 and 830nm therapy – a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury
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Lighting for clinical observation of cyanosis
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Low infra red laser light irradiation on cultured neural cells – effects on mitochrondria and cell viability after oxidative stress
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Low level light therapy increases mitochondrial membrane potential and ATP synthesis in C2C12 myotubes with a peak response at 3-6 hours
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Multiple roles of cytochrome c oxidase in mammalian cells uner action of red and ir-a radiation
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Photobiomodulation in human muscle tissue – an advantage in sports performance
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Regulation of skin collagen metabolism in vitro using a 660nm LED light source – clinical correlation with a single-blinded study
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Circadian Athletic and Sports Performance

Circadian variation in swim performance
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Circadian disruption and remedial interventions
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Circadian rhythms and enhanced athletic performance in the national football league
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Circadian rhythms in exercise performance – implications for hormonal and muscular adaptation
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Impact of the human circadian system, exercise, and their interaction on cardiovascular function
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The effects of sleep extension on the athletic performance of collegiate basketball players
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The stimulating effect of bright light on physical performance depends on internal time
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Seasonality

Long Days Enhance Recognition Memory and Increase Insulin-like growth factor 2 in the hippocampus
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Twilight

A colourful clock – van Diepen, Foster, Meijer – 2015
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Dawn and dusk simulation as a therapeutic intervention
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Impaired Circadian Photoentrainment in Opn-5 Null Mice
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Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulat – Storchi et al. – 2015
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Twilights widen the range of photic entrainment in hamsters
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Ultraviolet light provides a major input to non-image-forming light detection in mice – Van Oosterhout et al. – 2012
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